We are a company with a passion to deliver biomedical innovations to improve patient health, utilizing tools and principles from engineering, biomechanics, and mechanobiology.
Human-relevant preclinical models
We champion non-animal-based alternatives to replicate human physiology, diseases, and drug responses in preclinical drug discovery.
Problem
To demonstrate drug effectiveness faster, more efficiently, and at a lower cost and with greater content compared to existing in silico, cell, tissue, and animal models.
Solution
MechanoWell® utilizes viable human tissue slices, measures average stiffness and a local stiffness map, and is readily multiplexed with molecular endpoints.
Respiratory Drug Research
Asthma, COPD, lung cancer, pulmonary fibrosis, pneumonia, ARDS, and Ventilator Induced Lung Injury represent an enormous health burden and a leading cause of death.
Problem
The likelihood of a new respiratory drug entering the market has an appallingly low probability of 3%. This failure partly reflects the inability to screen ineffective drug candidates early in the discovery process.
Solution
Using lung physiology as the target, we provide bespoke solutions for drug screening, airway and vascular narrowing, computational modeling, image analysis, and structure-function assessment.